The Endocannabinoid System: Pivotal Orchestrator of Obesity and. Endocannabinoid system overactivity and the metabolic syndrome: Prospects for treatment. The endocannabinoid system (ECS) plays a physiologic role in modulating energy balance, feeding behavior, lipoprotein metabolism, insulin sensitivity, and glucose homeostasis, which when dysregulated can all contribute to cardiometabolic risk. Evidence has suggested that the ECS is overactive in human obesity and in animal models of genetic and diet- induced obesity. ECS stimulation centrally and peripherally drives metabolic processes that mimic the metabolic syndrome. These findings have led to the development of potential novel therapeutic targets, including the drug rimonabant, a selective CB1 receptor antagonist, which has been shown to promote weight loss, reduce inflammation, improve dyslipidemia, and improve glucose homeostasis. Read 'Endocannabinoids, metabolic regulation, and the role of diet' on DeepDyve - Instant access to the journals you need! Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to. Diet* Dietary Fats/metabolism; Endocannabinoids* Fatty. The recent description of the endocannabinoid. The endocannabinoid system has important. The Endocannabinoid System: Mechanisms Behind Metabolic. CB 1 knockout mice on the high-fat diet remained lean, with unchanged metabolic. The endocannabinoid system regulates numerous physiological processes, including intestinal function, glucose metabolism, and the stress response. Early Low-Fat Diet Enriched With Linolenic Acid Reduces Liver Endocannabinoid Tone and Improves Late Glycemic Control After a High-Fat Diet Challenge in Mice. The endocannabinoid system (ECS) plays a physiologic role in modulating energy balance, feeding behavior, lipoprotein metabolism, insulin sensitivity, and glucose. ![]()
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November 2017
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